This followed by a string of successful projects and leading roles in dramas such as the Philippine adaptation of My Girl (2008), action-melodramas Tayong Dalawa (2009), Kung Tayo'y Magkakalayo (2010), rom-com My Binondo Girl (2011–2012), family drama Ina, Kapatid, Anak (2012–2013) and period drama Ikaw Lamang (2014).She also starred in several films including Bride for Rent (2014), one of the highest grossing Filipino film of all time, grossing P326 million at the box office.She played a woman who is cured from glomerulonephritis through a healer, but must suffer a curse.From this film, she received a number of Best Supporting Actress nominations from almost all of the film award-giving bodies, missing only the Gawad Urian and The Young Critics' Circle.It was Chiu's first role as a villain and her first film to hit P100 million mark, with her receiving several nominations under different award giving bodies including PMPC, 12th Gawad PASADO Awards and the 34th MMFF for Best Supporting Actress.In October 2010, Chiu and Anderson teamed up for the last consecutive time in the film Till My Heartaches End.She and her siblings were raised by their paternal grandmother and, as children, frequently moved residencies in the Philippine Visayas; locating in Tacloban, Leyte, Cebu, Cagayan de Oro, General Santos City, Mindoro and back to Cebu City until 2006.Chiu has since participated in disaster relief organizations such as Philippine National Red Cross and Sagip Kapamilya.
In November 2017, She appears in the latest movie, The Ghost Bride where she plays the role as Mayen Lim who is the main protagonist of this film that she will be torn between living a normal though difficult life or accepting a strange business proposal called the Ghost Wedding in exchange for wealth and a comfortable life for her loved ones.
She and her on-screen partner Gerald Anderson became regulars in ASAP XV and appeared together in several ABS-CBN shows Love Spell, comedy sitcom Aalog-Alog and in the film First Day High.
In 2007, Chiu starred in the primetime TV series entitled Sana Maulit Muli alongside Anderson which was released to significant acclaim.
Her other high-profile films include I Love You, Goodbye (2009) and Bakit Hindi Ka Crush Ng Crush Mo? She has received a PMPC Award for Best Drama Actress, four FAMAS Award nominations (winning one) and was hailed Princess of Philippine Movies and TV for her accomplishments in the film and television industry.
For the show, Chiu left her hometown of Cebu City and moved to Manila.
She garnered several acting awards for her portrayal of Audrey, a woman who is loved by two military men.